microRNA-142 guards against autoimmunity by controlling Treg cell homeostasis and function.

microRNA-142 guards against autoimmunity by controlling Treg cell homeostasis and function.

Regulatory T (Treg) cells are critical in preventing aberrant immune responses. Posttranscriptional control of gene expression by microRNA (miRNA) has recently emerged as an essential genetic element for Treg cell function. Here, we report that mice with Treg cell-specific ablation of miR-142 (herea...

Full description

Bibliographic Details
Main Authors: Wei-Le Wang, Ching Ouyang, Natalie M Graham, Yuankun Zhang, Kaniel Cassady, Estefany Y Reyes, Min Xiong, Alicia M Davis, Kathie Tang, Defu Zeng, Mark P Boldin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-02-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001552

Internet

https://doi.org/10.1371/journal.pbio.3001552

Similar Items