Stabilizing DNA–Protein Co-Crystals via Intra-Crystal Chemical Ligation of the DNA

Protein and DNA co-crystals are most commonly prepared to reveal structural and functional details of DNA-binding proteins when subjected to X-ray diffraction. However, biomolecular crystals are notoriously unstable in solution conditions other than their native growth solution. To achieve greater a...

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Bibliographic Details
Main Authors: Abigail R. Orun, Sara Dmytriw, Ananya Vajapayajula, Christopher D. Snow
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Crystals
Subjects:
Online Access:https://www.mdpi.com/2073-4352/12/1/49