Synthesis, Labeling and Biological Evolution of New Thiopyrano[2,3-b]pyridine Derivatives as Potential Anticancer Agents
The new thiopyrano[2,3-b]pyridines 4–9 could be synthesized from the nicotinonitrile derivative 1. The cytotoxicity activity of the selected compounds 5, 6 and 8 was tested against MCF-7 and HCT-116 cell lines. The compound 5 (TP5) exhibited significant inhibitory activity and displayed the most pot...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Slovenian Chemical Society
2019-09-01
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| Series: | Acta Chimica Slovenica |
| Subjects: | |
| Online Access: | https://journals.matheo.si/index.php/ACSi/article/view/4980 |
| _version_ | 1811268598558097408 |
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| author | Mamdouh Sofan Wafaa Hamama Ibrahim Ibrahim EL-Hawary Ismail Taha Ibrahim Hanafi Hassan Zoorob |
| author_facet | Mamdouh Sofan Wafaa Hamama Ibrahim Ibrahim EL-Hawary Ismail Taha Ibrahim Hanafi Hassan Zoorob |
| author_sort | Mamdouh Sofan |
| collection | DOAJ |
| description | The new thiopyrano[2,3-b]pyridines 4–9 could be synthesized from the nicotinonitrile derivative 1. The cytotoxicity activity of the selected compounds 5, 6 and 8 was tested against MCF-7 and HCT-116 cell lines. The compound 5 (TP5) exhibited significant inhibitory activity and displayed the most potent activity, more than 6 and 8. The compound 5 with potent inhibitory activity in tumor growth inhibition would be a potential anticancer agent. In the light of this result, the labeled 125I-compound 5 (125I-TP5) was prepared and its cytotoxicity against ascites tumor in mice has been evaluated. The results show that compound 5 (TP5) may be potentially used as a radiopharmaceutical for tumor diagnosis when labeled with 125I. |
| first_indexed | 2024-04-12T21:25:49Z |
| format | Article |
| id | doaj.art-768b20b8657d4e86ac41452aaba285bf |
| institution | Directory Open Access Journal |
| issn | 1318-0207 1580-3155 |
| language | English |
| last_indexed | 2024-04-12T21:25:49Z |
| publishDate | 2019-09-01 |
| publisher | Slovenian Chemical Society |
| record_format | Article |
| series | Acta Chimica Slovenica |
| spelling | doaj.art-768b20b8657d4e86ac41452aaba285bf2022-12-22T03:16:10ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552019-09-0166359260210.17344/acsi.2019.4980730Synthesis, Labeling and Biological Evolution of New Thiopyrano[2,3-b]pyridine Derivatives as Potential Anticancer AgentsMamdouh Sofan0Wafaa Hamama1Ibrahim Ibrahim EL-Hawary2Ismail Taha Ibrahim3Hanafi Hassan Zoorob4Department of Chemistry, Faculty of Science, Damietta University, New Damietta 34517, EgyptChemistry Department, Faculty of Science, Mansoura University, EgyptChemistry Department, Faculty of Science, Damietta University, EgyptHot Laboratories Center, Atomic Energy Authority, Cairo, EgyptChemistry Department, Faculty of Science, Mansoura University, EgyptThe new thiopyrano[2,3-b]pyridines 4–9 could be synthesized from the nicotinonitrile derivative 1. The cytotoxicity activity of the selected compounds 5, 6 and 8 was tested against MCF-7 and HCT-116 cell lines. The compound 5 (TP5) exhibited significant inhibitory activity and displayed the most potent activity, more than 6 and 8. The compound 5 with potent inhibitory activity in tumor growth inhibition would be a potential anticancer agent. In the light of this result, the labeled 125I-compound 5 (125I-TP5) was prepared and its cytotoxicity against ascites tumor in mice has been evaluated. The results show that compound 5 (TP5) may be potentially used as a radiopharmaceutical for tumor diagnosis when labeled with 125I.https://journals.matheo.si/index.php/ACSi/article/view/4980Nicotinonitrilethiopyrano[2,3-b]pyridinecytototoxic activityascites tumor |
| spellingShingle | Mamdouh Sofan Wafaa Hamama Ibrahim Ibrahim EL-Hawary Ismail Taha Ibrahim Hanafi Hassan Zoorob Synthesis, Labeling and Biological Evolution of New Thiopyrano[2,3-b]pyridine Derivatives as Potential Anticancer Agents Acta Chimica Slovenica Nicotinonitrile thiopyrano[2,3-b]pyridine cytototoxic activity ascites tumor |
| title | Synthesis, Labeling and Biological Evolution of New Thiopyrano[2,3-b]pyridine Derivatives as Potential Anticancer Agents |
| title_full | Synthesis, Labeling and Biological Evolution of New Thiopyrano[2,3-b]pyridine Derivatives as Potential Anticancer Agents |
| title_fullStr | Synthesis, Labeling and Biological Evolution of New Thiopyrano[2,3-b]pyridine Derivatives as Potential Anticancer Agents |
| title_full_unstemmed | Synthesis, Labeling and Biological Evolution of New Thiopyrano[2,3-b]pyridine Derivatives as Potential Anticancer Agents |
| title_short | Synthesis, Labeling and Biological Evolution of New Thiopyrano[2,3-b]pyridine Derivatives as Potential Anticancer Agents |
| title_sort | synthesis labeling and biological evolution of new thiopyrano 2 3 b pyridine derivatives as potential anticancer agents |
| topic | Nicotinonitrile thiopyrano[2,3-b]pyridine cytototoxic activity ascites tumor |
| url | https://journals.matheo.si/index.php/ACSi/article/view/4980 |
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