Expansion and activation of monocytic-myeloid-derived suppressor cell via STAT3/arginase-I signaling in patients with ankylosing spondylitis

Expansion and activation of monocytic-myeloid-derived suppressor cell via STAT3/arginase-I signaling in patients with ankylosing spondylitis

Abstract Background Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease. The dysregulated immune system plays an important role in the pathogenesis of AS. Myeloid-derived suppressor cells (MDSCs) play a key immunoregulatory role in autoimmune arthritis. The aim of this study was...

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Bibliographic Details
Main Authors: Yu-feng Liu, Kun-hai Zhuang, Bin Chen, Pei-wu Li, Xuan Zhou, Hua Jiang, Li-mei Zhong, Feng-bin Liu
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Arthritis Research & Therapy
Subjects:
Ankylosing spondylitis
Myeloid-derived suppressor cells
STAT3/arginase-I signaling
T cell suppression
Online Access:http://link.springer.com/article/10.1186/s13075-018-1654-4

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http://link.springer.com/article/10.1186/s13075-018-1654-4

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