Two HCN4 Channels Play Functional Roles in the Zebrafish Heart

The HCN4 channel is essential for heart rate regulation in vertebrates by generating pacemaker potentials in the sinoatrial node. HCN4 channel abnormality may cause bradycardia and sick sinus syndrome, making it an important target for clinical research and drug discovery. The zebrafish is a popular...

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Bibliographic Details
Main Authors: Jiaying Liu, Go Kasuya, Buntaro Zempo, Koichi Nakajo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Physiology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.901571/full