Structural basis of peptide secretion for Quorum sensing by ComA

Abstract Quorum sensing (QS) is a crucial regulatory mechanism controlling bacterial signalling and holds promise for novel therapies against antimicrobial resistance. In Gram-positive bacteria, such as Streptococcus pneumoniae, ComA is a conserved efflux pump responsible for the maturation and secr...

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Bibliographic Details
Main Authors: Lin Yu, Xin Xu, Wan-Zhen Chua, Hao Feng, Zheng Ser, Kai Shao, Jian Shi, Yumei Wang, Zongli Li, Radoslaw M. Sobota, Lok-To Sham, Min Luo
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42852-9