Trigonelline reverses high glucose-induced proliferation, fibrosis of mesangial cells via modulation of Wnt signaling pathway

Trigonelline reverses high glucose-induced proliferation, fibrosis of mesangial cells via modulation of Wnt signaling pathway

Abstract Background Diabetic nephropathy (DN) is the leading cause of the end-stage renal disease (ESRD). The proliferation and apoptosis of mesangial cells induced by the activated Wnt/β-catenin pathway is crucial in DN. Trigonelline (TRL) is an alkaloid that has been shown to decrease proteinuria...

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Bibliographic Details
Main Authors: Chen Chen, Yan Shi, Jiulong Ma, Zhen Chen, Ming Zhang, Yan Zhao
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Diabetic nephropathy
Trigonelline
Mesangial cells
Wnt/β-catenin
Apoptosis
Online Access:https://doi.org/10.1186/s13098-022-00798-w

Internet

https://doi.org/10.1186/s13098-022-00798-w

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