An essential role for miR-15/16 in Treg suppression and restriction of proliferation

An essential role for miR-15/16 in Treg suppression and restriction of proliferation

Summary: The miR-15/16 family targets a large network of genes in T cells to restrict their cell cycle, memory formation, and survival. Upon T cell activation, miR-15/16 are downregulated, allowing rapid expansion of differentiated effector T cells to mediate a sustained response. Here, we used cond...

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Bibliographic Details
Main Authors: Kristina Johansson, John D. Gagnon, Simon K. Zhou, Marlys S. Fassett, Andrew W. Schroeder, Robin Kageyama, Rodriel A. Bautista, Hewlett Pham, Prescott G. Woodruff, K. Mark Ansel
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723013104

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http://www.sciencedirect.com/science/article/pii/S2211124723013104

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