Betulin Promotes Differentiation of Human Osteoblasts In Vitro and Exerts an Osteoinductive Effect on the hFOB 1.19 Cell Line Through Activation of JNK, ERK1/2, and mTOR Kinases

Betulin Promotes Differentiation of Human Osteoblasts In Vitro and Exerts an Osteoinductive Effect on the hFOB 1.19 Cell Line Through Activation of JNK, ERK1/2, and mTOR Kinases

Although betulin (BET), a naturally occurring pentacyclic triterpene, has a variety of biological activities, its osteogenic potential has not been investigated so far. The aim of this study was to assess the effect of BET on differentiation of human osteoblasts (hFOB 1.19 and Saos-2 cells) in vitro...

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Bibliographic Details
Main Authors: Magdalena Mizerska-Kowalska, Adrianna Sławińska-Brych, Katarzyna Kaławaj, Aleksandra Żurek, Beata Pawińska, Wojciech Rzeski, Barbara Zdzisińska
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Molecules
Subjects:
betulin
osteoblasts
differentiation
mineralization
Online Access:https://www.mdpi.com/1420-3049/24/14/2637

Internet

https://www.mdpi.com/1420-3049/24/14/2637

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