Dextramabs: A Novel Format of Antibody‐Drug Conjugates Featuring a Multivalent Polysaccharide Scaffold

Dextramabs: A Novel Format of Antibody‐Drug Conjugates Featuring a Multivalent Polysaccharide Scaffold

Abstract Antibody‐drug conjugates (ADCs) are multicomponent biomolecules that have emerged as a powerful tool for targeted tumor therapy. Combining specific binding of an immunoglobulin with toxic properties of a payload, they however often suffer from poor hydrophilicity when loaded with a high amo...

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Bibliographic Details
Main Authors: Hendrik Schneider, Lukas Deweid, Thomas Pirzer, Desislava Yanakieva, Simon Englert, Bastian Becker, Dr. Olga Avrutina, Prof. Dr. Harald Kolmar
Format: Article
Language:English
Published: Wiley-VCH 2019-03-01
Series:ChemistryOpen
Subjects:
ADC
bioconjugation
dextran modification
cancer
drug discovery
Online Access:https://doi.org/10.1002/open.201900066

Internet

https://doi.org/10.1002/open.201900066

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