Single‐cell transcriptome profiling reveals the key role of ZNF683 in natural killer cell exhaustion in multiple myeloma

Single‐cell transcriptome profiling reveals the key role of ZNF683 in natural killer cell exhaustion in multiple myeloma

Abstract Backgrounds Decreased cytotoxicity of natural killer (NK) cells has been shown in multiple myeloma (MM). However, the underlying molecular mechanisms remain unclear. Here, by using single‐cell RNA sequencing analysis and in vitro experiments, we aim to uncover and validate molecularly disti...

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Bibliographic Details
Main Authors: Xin Li, Mengping Chen, Yike Wan, Lu Zhong, Xiaofeng Han, Xiaotong Chen, Fei Xiao, Jia Liu, Yiwei Zhang, Di Zhu, Jing Xiang, Junling Liu, Honghui Huang, Jian Hou
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:Clinical and Translational Medicine
Subjects:
exhaustion
multiple myeloma
natural killer cells
SH2D1B
ZNF683
Online Access:https://doi.org/10.1002/ctm2.1065

Internet

https://doi.org/10.1002/ctm2.1065

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