P2Y6 receptor-mediated signaling amplifies TLR-induced pro-inflammatory responses in microglia

TLR-induced signaling initiates inflammatory responses in cells of the innate immune system. These responses are amongst others characterized by the secretion of high levels of pro-inflammatory cytokines, which are tightly regulated and adapted to the microenvironment. Purinergic receptors are power...

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Bibliographic Details
Main Authors: Raissa Timmerman, Ella A. Zuiderwijk-Sick, Jeffrey J. Bajramovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.967951/full