S1PR1 mediates Th17 cell migration from the thymus to the skin in health and disease

Th17 cells play crucial roles in host defense and the pathogenesis of autoimmune diseases in the skin. While their differentiation mechanisms have been extensively studied, the origin of skin Th17 cells remains unclear. In this study, we analyzed single-cell RNA-sequencing data and identify the pres...

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Bibliographic Details
Main Authors: Jonas Engesser, Huiying Wang, Sonja Kapffer, Anna Kaffke, Anett Peters, Hans-Joachim Paust, Markus Geissen, Christian F. Krebs, Ulf Panzer, Nariaki Asada
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1473130/full