Macrophages and Galectin 3 Control Bacterial Burden in Acute and Subacute Murine Leptospirosis That Determines Chronic Kidney Fibrosis

Macrophages and Galectin 3 Control Bacterial Burden in Acute and Subacute Murine Leptospirosis That Determines Chronic Kidney Fibrosis

Previous studies have suggested that macrophages may contribute to acute Leptospira dissemination, as well as having a major role in kidney fibrosis. Our aim was to characterize the role of macrophages and galectin 3 (Gal-3) on the survival, clinical course, bacterial burden, interstitial nephritis,...

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Bibliographic Details
Main Authors: María F. Ferrer, Emilia Scharrig, Nancy Charo, Ana L. Rípodas, Ricardo Drut, Eugenio A. Carrera Silva, Ariel Nagel, Jarlath E. Nally, Daniela P. Montes de Oca, Mirta Schattner, Ricardo M. Gómez
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
macrophages
galectin 3
fibrosis
Leptospira
pathogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00384/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2018.00384/full

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