Cell surface-bound La protein regulates the cell fusion stage of osteoclastogenesis
Bone maintenance in health and disease depends on bone-resorbing osteoclasts. Whitlock et al. demonstrate that an RNA chaperon -La protein- lives a second life as a key regulator of osteoclast size and function, suggesting a new therapeutic target.
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-02-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-36168-x |