Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate.

Neurogenin 3 (NGN3) is necessary and sufficient for endocrine differentiation during pancreatic development and is expressed by a population of progenitor cells that give rise exclusively to hormone-secreting cells within islets. NGN3 protein can be detected in the adult rodent pancreas only followi...

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Bibliographic Details
Main Authors: Danielle L Gomez, Marci O'Driscoll, Timothy P Sheets, Ralph H Hruban, Jose Oberholzer, James J McGarrigle, Michael J Shamblott
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4545947?pdf=render