EPISCORE: cell type deconvolution of bulk tissue DNA methylomes from single-cell RNA-Seq data

EPISCORE: cell type deconvolution of bulk tissue DNA methylomes from single-cell RNA-Seq data

Abstract Cell type heterogeneity presents a challenge to the interpretation of epigenome data, compounded by the difficulty in generating reliable single-cell DNA methylomes for large numbers of cells and samples. We present EPISCORE, a computational algorithm that performs virtual microdissection o...

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Bibliographic Details
Main Authors: Andrew E. Teschendorff, Tianyu Zhu, Charles E. Breeze, Stephan Beck
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Genome Biology
Subjects:
DNA methylation
EWAS
Single-cell RNA-Seq
Online Access:http://link.springer.com/article/10.1186/s13059-020-02126-9

Internet

http://link.springer.com/article/10.1186/s13059-020-02126-9

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