Molecular mechanism of phospholipid transport at the bacterial outer membrane interface

Abstract The outer membrane (OM) of Gram-negative bacteria is an asymmetric lipid bilayer with outer leaflet lipopolysaccharides and inner leaflet phospholipids (PLs). This unique lipid asymmetry renders the OM impermeable to external insults, including antibiotics and bile salts. To maintain this b...

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Bibliographic Details
Main Authors: Jiang Yeow, Min Luo, Shu-Sin Chng
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44144-8