Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses

Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses

Anastomotic leakage (AL) accounts for a major part of in-house mortality in patients undergoing colorectal surgery. Local ischemia and abdominal sepsis are common risk factors contributing to AL and are characterized by upregulation of the hypoxia-inducible factor (HIF) pathway. The HIF pathway is c...

Полное описание

Библиографические подробности
Главные авторы: Moritz J. Strowitzki, Gwendolyn Kimmer, Julian Wehrmann, Alina S. Ritter, Praveen Radhakrishnan, Vanessa M. Opitz, Christopher Tuffs, Marvin Biller, Julia Kugler, Ulrich Keppler, Jonathan M. Harnoss, Johannes Klose, Thomas Schmidt, Alfonso Blanco, Cormac T. Taylor, Martin Schneider
Формат: Статья
Язык:English
Опубликовано: American Society for Clinical investigation 2021-04-01
Серии:JCI Insight
Предметы:
Gastroenterology
Inflammation
Online-ссылка:https://doi.org/10.1172/jci.insight.139191

Internet

https://doi.org/10.1172/jci.insight.139191

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