Different transport routes for high density lipoprotein and its associated free sterol in polarized hepatic cells

We analyzed the intracellular transport of HDL and its associated free sterol in polarized human hepatoma HepG2 cells. Using pulse-chase protocols, we demonstrated that HDL labeled with Alexa 488 at the apolipoprotein (Alexa 488-HDL) was internalized by a scavenger receptor class B type I (SR-BI)-de...

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Bibliographic Details
Main Authors: Daniel Wüstner, Mousumi Mondal, Amy Huang, Frederick R. Maxfield
Format: Article
Language:English
Published: Elsevier 2004-03-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520318708