Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2

Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2

Summary: Glycyrrhetinic acid (GA) is a natural product of licorice with mitochondria targeting properties and shows broad anticancer activities, but its targets and underlying mechanisms remain elusive. Here, we identified the mitochondrial enzyme serine hydroxymethyltransferase 2 (SHMT2) as a targe...

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Bibliographic Details
Main Authors: Xiuxiu Jin, Li Li, Qinlu Peng, Chunmei Gan, Li Gao, Siyu He, Shuangyan Tan, Wenchen Pu, Yu Liu, Yanqiu Gong, Yuqin Yao, Gang Wang, Xiaohui Liu, Meng Gong, Peng Lei, Huiyuan Zhang, Shiqian Qi, Heng Xu, Hongbo Hu, Biao Dong, Yong Peng, Dan Su, Lunzhi Dai
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:iScience
Subjects:
Biochemistry
Natural product biochemistry
Omics
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222006204

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http://www.sciencedirect.com/science/article/pii/S2589004222006204

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