International cohort study indicates no association between alpha-1 blockers and susceptibility to COVID-19 in benign prostatic hyperplasia patients

International cohort study indicates no association between alpha-1 blockers and susceptibility to COVID-19 in benign prostatic hyperplasia patients

Purpose: Alpha-1 blockers, often used to treat benign prostatic hyperplasia (BPH), have been hypothesized to prevent COVID-19 complications by minimising cytokine storm release. The proposed treatment based on this hypothesis currently lacks support from reliable real-world evidence, however. We lev...

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Bibliographic Details
Main Authors: Akihiko Nishimura, Junqing Xie, Kristin Kostka, Talita Duarte-Salles, Sergio Fernández Bertolín, María Aragón, Clair Blacketer, Azza Shoaibi, Scott L. DuVall, Kristine Lynch, Michael E. Matheny, Thomas Falconer, Daniel R. Morales, Mitchell M. Conover, Seng Chan You, Nicole Pratt, James Weaver, Anthony G. Sena, Martijn J. Schuemie, Jenna Reps, Christian Reich, Peter R. Rijnbeek, Patrick B. Ryan, George Hripcsak, Daniel Prieto-Alhambra, Marc A. Suchard
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
treatment for SARS CoV-2
observational study
electronic health records
federated data model
causal inference
open science
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.945592/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.945592/full

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