Antibodies to Crucial Epitopes on HSV-2 Glycoprotein D as a Guide to Dosing an mRNA Genital Herpes Vaccine

Antibodies to Crucial Epitopes on HSV-2 Glycoprotein D as a Guide to Dosing an mRNA Genital Herpes Vaccine

The toxicity of mRNA-lipid nanoparticle (LNP) vaccines depends on the total mRNA-LNP dose. We established that the maximum tolerated dose of our trivalent mRNA-LNP genital herpes vaccine was 10 μg/immunization in mice. We then evaluated one of the mRNAs, gD2 mRNA-LNP, to determine how much of the 10...

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Bibliographic Details
Main Authors: Lauren M. Hook, Sita Awasthi, Tina M. Cairns, Mohamad-Gabriel Alameh, Bernard T. Fowler, Kevin P. Egan, Molly M. H. Sung, Drew Weissman, Gary H. Cohen, Harvey M. Friedman
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Viruses
Subjects:
herpes simplex virus type 2
nucleoside-modified mRNA
lipid nanoparticle
glycoprotein D
genital herpes vaccine
IgG ELISA
Online Access:https://www.mdpi.com/1999-4915/14/3/540

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https://www.mdpi.com/1999-4915/14/3/540

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