Asymmetric Synthesis and Cytotoxicity Evaluation of Right-Half Models of Antitumor Renieramycin Marine Natural Products

A general protocol for the asymmetric synthesis of 3-<i>N</i>-arylmethylated right-half model compounds of renieramycins was developed, which enabled structure&#8315;activity relationship (SAR) study of several 3-<i>N</i>-arylmethyl derivatives. The most active compound (...

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Bibliographic Details
Main Authors: Takehiro Matsubara, Masashi Yokoya, Natchanun Sirimangkalakitti, Naoki Saito
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Marine Drugs
Subjects:
Online Access:https://www.mdpi.com/1660-3397/17/1/3