Brain insulin sensitivity is linked to adiposity and body fat distribution

Brain insulin sensitivity is linked to adiposity and body fat distribution

Brain insulin action regulates eating behavior and whole-body energy fluxes, however the impact of brain insulin resistance on long-term weight and body fat composition is unknown. Here, the authors show that high brain insulin sensitivity is linked to weight loss during lifestyle intervention and a...

Full description

Bibliographic Details
Main Authors:	Stephanie Kullmann, Vera Valenta, Robert Wagner, Otto Tschritter, Jürgen Machann, Hans-Ulrich Häring, Hubert Preissl, Andreas Fritsche, Martin Heni
Format:	Article
Language:	English
Published:	Nature Portfolio 2020-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-15686-y

Similar Items

Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger
by: Stephanie Kullmann, et al.
Published: (2017-05-01)

Reduced cortical thickness associated with visceral fat and BMI
by: Ralf Veit, et al.
Published: (2014-01-01)

Dissociation of GLP-1 and insulin association with food processing in the brain: GLP-1 sensitivity despite insulin resistance in obese humans
by: Martin Heni, et al.
Published: (2015-12-01)

The insulin-mediated modulation of visually evoked magnetic fields is reduced in obese subjects.
by: Martina Guthoff, et al.
Published: (2011-01-01)

Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese
by: Stephanie Kullmann, et al.
Published: (2022-09-01)

Functional Connectivity Within the Gustatory Network Is Altered by Fat Content and Oral Fat Sensitivity – A Pilot Study
by: Sabine Frank-Podlech, et al.
Published: (2019-07-01)

Insulin modulation of magnetoencephalographic resting state dynamics in lean and obese subjects
by: Krunoslav T Stingl, et al.
Published: (2010-12-01)

Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test
by: Rohit Babbar, et al.
Published: (2018-03-01)

Family History of Diabetes Is Associated With Delayed Fetal Postprandial Brain Activity
by: Franziska Schleger, et al.
Published: (2018-11-01)

Normalized Indices Derived from Visceral Adipose Mass Assessed by Magnetic Resonance Imaging and Their Correlation with Markers for Insulin Resistance and Prediabetes
by: Jürgen Machann, et al.
Published: (2020-07-01)

No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men
by: Andreas Vosseler, et al.
Published: (2020-11-01)

Gene x Gene Interactions Highlight the Role of Incretin Resistance for Insulin Secretion
by: Benjamin Assad Jaghutriz, et al.
Published: (2019-02-01)

No Effect of Lifestyle Intervention during Third Trimester on Brain Programming in Fetuses of Mothers with Gestational Diabetes
by: Franziska Schleger, et al.
Published: (2021-02-01)

Common genetic variation in the human CTF1 locus, encoding cardiotrophin-1, determines insulin sensitivity.
by: Stefan Z Lutz, et al.
Published: (2014-01-01)

Maternal Weight Gain during Pregnancy and the Developing Autonomic Nervous System—Possible Impact of GDM
by: Louise Fritsche, et al.
Published: (2022-12-01)

Detection of diabetes from whole-body MRI using deep learning
by: Benedikt Dietz, et al.
Published: (2021-11-01)

Reduced insulin clearance is linked to subclinical atherosclerosis in individuals at risk for type 2 diabetes mellitus
by: Elko Randrianarisoa, et al.
Published: (2020-12-01)

The brain response to peripheral insulin declines with age: a contribution of the blood-brain barrier?
by: Tina Sartorius, et al.
Published: (2015-01-01)

DPP4 gene variation affects GLP-1 secretion, insulin secretion, and glucose tolerance in humans with high body adiposity.
by: Anja Böhm, et al.
Published: (2017-01-01)

Long-term stabilization effects of leptin on brain functions in a leptin-deficient patient.
by: Sabine Frank, et al.
Published: (2013-01-01)

Slow deep breathing modulates cardiac vagal activity but does not affect peripheral glucose metabolism in healthy men
by: Andreas Vosseler, et al.
Published: (2021-10-01)

Sustained Treatment with Insulin Detemir in Mice Alters Brain Activity and Locomotion.
by: Tina Sartorius, et al.
Published: (2016-01-01)

What role do fat cells play in pancreatic tissue?
by: Felicia Gerst, et al.
Published: (2019-07-01)

New genetic loci link adipose and insulin biology to body fat distribution
by: Shungin, Dmitry, et al.
Published: (2015)

Free fatty acids, glicentin and glucose-dependent insulinotropic polypeptide as potential major determinants of fasting substrate oxidation
by: Julia Hummel, et al.
Published: (2021-08-01)

Postprandial Dynamics of Proglucagon Cleavage Products and Their Relation to Metabolic Health
by: Robert Wagner, et al.
Published: (2022-06-01)

High Protein Diets Improve Liver Fat and Insulin Sensitivity by Prandial but Not Fasting Glucagon Secretion in Type 2 Diabetes
by: Jiudan Zhang, et al.
Published: (2022-05-01)

Diabetes and the Prostate: Elevated Fasting Glucose, Insulin Resistance and Higher Levels of Adrenal Steroids in Prostate Cancer
by: Stefan Zoltán Lutz, et al.
Published: (2022-11-01)

The German Gestational Diabetes Study (PREG), a prospective multicentre cohort study: rationale, methodology and design
by: Andreas Fritsche, et al.
Published: (2022-02-01)

Reproducibility and discrimination of different indices of insulin sensitivity and insulin secretion
by: Sarah Hudak, et al.
Published: (2021-01-01)

Insulin promotes glycogen storage and cell proliferation in primary human astrocytes.
by: Martin Heni, et al.
Published: (2011-01-01)

Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity.
by: Harald Staiger, et al.
Published: (2013-01-01)

No association between variation in the <it>NR4A1 </it>gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes
by: Fritsche Andreas, et al.
Published: (2010-06-01)

Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function.
by: Harald Staiger, et al.
Published: (2007-01-01)

Glucose-Raising Polymorphisms in the Human Clock Gene Cryptochrome 2 (CRY2) Affect Hepatic Lipid Content.
by: Fausto Machicao, et al.
Published: (2016-01-01)

Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin.
by: Robert Wagner, et al.
Published: (2011-01-01)

Extracellular Matrix Expression in Human Pancreatic Fat Cells of Patients with Normal Glucose Regulation, Prediabetes and Type 2 Diabetes
by: Dorothea Siegel-Axel, et al.
Published: (2023-07-01)

Sex-Specific Associations of Testosterone With Metabolic Traits
by: Stefan Z. Lutz, et al.
Published: (2019-03-01)

FTO Genotype Interacts with Improvement in Aerobic Fitness on Body Weight Loss During Lifestyle Intervention
by: Corinna Sailer, et al.
Published: (2016-06-01)

Evaluation of fasting state-/oral glucose tolerance test-derived measures of insulin release for the detection of genetically impaired β-cell function.
by: Silke A Herzberg-Schäfer, et al.
Published: (2010-12-01)