Seventy-Two-Hour LRRK2 Kinase Activity Inhibition Increases Lysosomal GBA Expression in H4, a Human Neuroglioma Cell Line

Seventy-Two-Hour LRRK2 Kinase Activity Inhibition Increases Lysosomal GBA Expression in H4, a Human Neuroglioma Cell Line

Mutations in LRRK2 and GBA1 are key contributors to genetic risk of developing Parkinson’s disease (PD). To investigate how LRRK2 kinase activity interacts with GBA and contributes to lysosomal dysfunctions associated with the pathology of PD. The activity of the lysosomal enzyme β-Glucocerebrosidas...

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Bibliographic Details
Main Authors: Clara Ruz, José Luis Alcantud, Francisco Vives, Francisco Arrebola, John Hardy, Patrick A. Lewis, Claudia Manzoni, Raquel Duran
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
LRRK2
lysosomal dysfunction
glucocerebrosidase
Parkinson’s disease
autophagy
Online Access:https://www.mdpi.com/1422-0067/23/13/6935

Internet

https://www.mdpi.com/1422-0067/23/13/6935

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