Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis

Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis

Abstract The nucleoside adenosine is a potent regulator of vascular homeostasis, but it remains unclear how expression or function of the adenosine‐metabolizing enzyme adenosine kinase (ADK) and the intracellular adenosine levels influence angiogenesis. We show here that hypoxia lowered the expressi...

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Bibliographic Details
Main Authors: Yiming Xu, Yong Wang, Siyuan Yan, Yaqi Zhou, Qiuhua Yang, Yue Pan, Xianqiu Zeng, Xiaofei An, Zhiping Liu, Lina Wang, Jiean Xu, Yapeng Cao, David J Fulton, Neal L Weintraub, Zsolt Bagi, Md Nasrul Hoda, Xiaoling Wang, Qinkai Li, Mei Hong, Xuejun Jiang, Detlev Boison, Christian Weber, Chaodong Wu, Yuqing Huo
Format: Article
Language:English
Published: Springer Nature 2017-09-01
Series:EMBO Molecular Medicine
Subjects:
adenosine
adenosine kinase
angiogenesis
DNA methylation
endothelial cells
Online Access:https://doi.org/10.15252/emmm.201607066

Internet

https://doi.org/10.15252/emmm.201607066

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