Novel Uracil-Based Inhibitors of Acetylcholinesterase with Potency for Treating Memory Impairment in an Animal Model of Alzheimer’s Disease

Novel Uracil-Based Inhibitors of Acetylcholinesterase with Potency for Treating Memory Impairment in an Animal Model of Alzheimer’s Disease

Novel derivatives based on 6-methyluracil and condensed uracil, 2,4-quinazoline-2,4-dione, were synthesized with terminal <i>meta</i>- and <i>para</i>-benzoate moieties in polymethylene chains at the N atoms of the pyrimidine ring. In the synthesized compounds, the polymethyl...

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Bibliographic Details
Main Authors: Vyacheslav E. Semenov, Irina V. Zueva, Sofya V. Lushchekina, Eduard G. Suleimanov, Liliya M. Gubaidullina, Marina M. Shulaeva, Oksana A. Lenina, Konstantin A. Petrov
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
acetylcholinesterase
6-methyluracil
inhibitors
peripheral anionic site
Alzheimer’s disease
Online Access:https://www.mdpi.com/1420-3049/27/22/7855

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https://www.mdpi.com/1420-3049/27/22/7855

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