Adhesion-clutch between DCC and netrin-1 mediates netrin-1–induced axonal haptotaxis

The growth cone, a motile structure located at the tip of growing axons, senses extracellular guidance cues and translates them into directional forces that drive axon outgrowth and guidance. Axon guidance directed by chemical cues on the extracellular adhesive substrate is termed haptotaxis. Recent...

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Bibliographic Details
Main Authors: Zhen Qiu, Takunori Minegishi, Daichi Aoki, Kouki Abe, Kentarou Baba, Naoyuki Inagaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1307755/full