Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank

Abstract In just over a decade, advances in genome-wide association studies (GWAS) have offered an approach to stratify individuals based on genetic risk for disease. Using recent Alzheimer's disease (AD) GWAS results as the base data, we determined each individual's polygenic risk score (...

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Bibliographic Details
Main Authors: Catarina Gouveia, Elizabeth Gibbons, Nadia Dehghani, James Eapen, Rita Guerreiro, Jose Bras
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-12391-2