Metabolism-dependent ferroptosis promotes mitochondrial dysfunction and inflammation in CD4+ T lymphocytes in HIV-infected immune non-respondersResearch in context

Metabolism-dependent ferroptosis promotes mitochondrial dysfunction and inflammation in CD4+ T lymphocytes in HIV-infected immune non-respondersResearch in context

Summary: Background: HIV immune non-responders (INRs) are described as a failure to reestablish a pool of CD4+ T lymphocytes (CD4 cells) after antiretroviral therapy (ART), which is related to poor clinical results. Ferroptosis is a newly discovered form of cell death characterised by iron-dependen...

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Bibliographic Details
Main Authors: Qing Xiao, Liting Yan, Junyan Han, Siyuan Yang, Yunxia Tang, Qun Li, Xiaojie Lao, Zhen Chen, Jiang Xiao, Hongxin Zhao, Fengting Yu, Fujie Zhang
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:EBioMedicine
Subjects:
Human immunodeficiency virus (HIV)
Poor immune reconstitution (PIR)
Immune non-responder (INR)
Ferroptosis
Metabolism
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422005643

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http://www.sciencedirect.com/science/article/pii/S2352396422005643

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