Metabolism-dependent ferroptosis promotes mitochondrial dysfunction and inflammation in CD4+ T lymphocytes in HIV-infected immune non-respondersResearch in context

Metabolism-dependent ferroptosis promotes mitochondrial dysfunction and inflammation in CD4+ T lymphocytes in HIV-infected immune non-respondersResearch in context

Summary: Background: HIV immune non-responders (INRs) are described as a failure to reestablish a pool of CD4+ T lymphocytes (CD4 cells) after antiretroviral therapy (ART), which is related to poor clinical results. Ferroptosis is a newly discovered form of cell death characterised by iron-dependen...

Full description

Bibliographic Details
Main Authors:	Qing Xiao, Liting Yan, Junyan Han, Siyuan Yang, Yunxia Tang, Qun Li, Xiaojie Lao, Zhen Chen, Jiang Xiao, Hongxin Zhao, Fengting Yu, Fujie Zhang
Format:	Article
Language:	English
Published:	Elsevier 2022-12-01
Series:	EBioMedicine
Subjects:	Human immunodeficiency virus (HIV) Poor immune reconstitution (PIR) Immune non-responder (INR) Ferroptosis Metabolism Inflammation
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396422005643

Similar Items

Alterations in circulating markers in HIV/AIDS patients with poor immune reconstitution: Novel insights from microbial translocation and innate immunity
by: Qing Xiao, et al.
Published: (2022-10-01)

Adjuvant sildenafil therapy in poor responders undergoing in vitro fertilization: A prospective,
by: Walid M. Ataalla, et al.
Published: (2016-09-01)

Stubborn Exercise Responders–Where to Next?
by: Leo R. Bell, et al.
Published: (2022-06-01)

Soft versus Conventional Protocol in Ovarian Stimulation in Intracytoplasmic Sperm Injection Cycles for Poor Responders: A randomized clinical trial
by: Abd El-Naser Abd El-Gaber Ali, et al.
Published: (2022-01-01)

Elucidating the Gene Signatures and Immune Cell Types in HIV-Infected Immunological Non-Responders by Bioinformatics Analyses
by: Xiao Q, et al.
Published: (2022-12-01)

Pyroptosis associated with immune reconstruction failure in HIV-1- infected patients receiving antiretroviral therapy: a cross-sectional study
by: Xiaojie Lao, et al.
Published: (2022-11-01)

Editorial: Challenges and solutions for the incomplete immune restoration in HIV-infected patients under antiretroviral therapy
by: Yi-Qun Kuang, et al.
Published: (2023-06-01)

Corifollitropin alfa for poor responders patients, a prospective randomized study
by: F. M. Fusi, et al.
Published: (2020-07-01)

CD70-induced differentiation of proinflammatory Th1/17/22/GM lymphocytes associated with disease progression and immune reconstitution during HIV infection
by: Xinyue Wang, et al.
Published: (2023-12-01)

Trismus and voice change after starting tuberculosis treatment
by: Joseph M. Rocco, et al.
Published: (2021-01-01)

Pathological proliferation: a potential mechanism for poor CD4+ T cell recovery in people living with HIV
by: Yang Zhang, et al.
Published: (2024-03-01)

What Is the Best Regimen for Ovarian Stimulation of Poor Responders in ART/IVF?
by: Zeev Blumenfeld
Published: (2020-04-01)

Controlled ovulation of the dominant follicle using progestin in minimal stimulation in poor responders
by: Qiuju Chen, et al.
Published: (2017-09-01)

Low double-negative CD3+CD4-CD8- T cells are associated with incomplete restoration of CD4+ T cells and higher immune activation in HIV-1 immunological non-responders
by: Xiaofan LU, et al.
Published: (2016-12-01)

Demographic characteristics and clinical profile of poor responders in IVF / ICSI: A comparative study
by: Nabaneeta Padhy, et al.
Published: (2010-01-01)

How Can We Predict Success in Poor Responders?
by: Alina Elena BORDEA, et al.
Published: (2021-12-01)

Thymic Exhaustion and Increased Immune Activation Are the Main Mechanisms Involved in Impaired Immunological Recovery of HIV-Positive Patients under ART
by: Maria Carolina Dos Santos Guedes, et al.
Published: (2023-02-01)

Anti-SARS-COV-2 specific immunity in HIV immunological non-responders after mRNA-based COVID-19 vaccination
by: Marta Sisteré-Oró, et al.
Published: (2022-08-01)

Does daily co administration of gonadotropins and letrozole during the ovarian stimulation improve IVF outcome for poor and sub optimal responders?
by: Moran Shapira, et al.
Published: (2020-06-01)

Transrectal versus transabdominal ultrasound-guided embryo transfer in obese poor responders
by: Sameh Salama, et al.
Published: (2022-01-01)

Ferroptosis, autophagy, tumor and immunity
by: Yuyan Xie, et al.
Published: (2023-09-01)

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity
by: Rong Tang, et al.
Published: (2020-08-01)

Dehydroepiandrosterone supplementation and the impact of follicular fluid metabolome and cytokinome profiles in poor ovarian responders
by: Veronique Viardot-Foucault, et al.
Published: (2023-06-01)

Research Progress on Ferroptosis-mediated Antitumor Immunotherapy
by: HUANG Guiqin, et al.
Published: (2023-07-01)

The Dietary Inflammatory Index Is Not Associated With Gut Permeability or Biomarkers of Systemic Inflammation in HIV Immunologic Non-responders
by: Fat Malazogu, et al.
Published: (2021-11-01)

Tuberculosis IRIS: Pathogenesis, Presentation, and Management across the Spectrum of Disease
by: Carson M. Quinn, et al.
Published: (2020-10-01)

Immune reconstitution inflammatory syndrome associated with pulmonary sarcoidosis in an HIV-infected patient: an immunohistochemical study
by: Érique José Peixoto de Miranda, et al.

Advances in Human Immune System Mouse Models for Studying Human Hematopoiesis and Cancer Immunotherapy
by: Syed A. Mian, et al.
Published: (2021-02-01)

Recent advances in poor HIV immune reconstitution: what will the future look like?
by: Wenyuan Zhang, et al.
Published: (2023-08-01)

Immune reconstitution inflammatory syndrome-associated disseminated Kaposi's sarcoma in a patient infected with human immunodeficiency virus: Report of an autopsy case
by: Chiu-Hsuan Cheng, et al.
Published: (2017-01-01)

Heterogeneity Among Poor Ovarian Responders According to Bologna Criteria Results in Diverging Cumulative Live Birth Rates
by: Alessia Romito, et al.
Published: (2020-04-01)

Outcomes of High Initial Daily Doses of Gonadotropin in Patients With Poor Ovarian Reserve
by: Li-Ling Chou, et al.
Published: (2010-12-01)

Clinical Effects of a Microdose GnRH Agonist Flare Regimen Administered to Poor Responders Undergoing ART Cycles
by: Robab Davar, et al.
Published: (2009-08-01)

Clinical Effects of a Microdose GnRH Agonist Flare Regimen Administered to Poor Responders Undergoing ART Cycles
by: Aflatoonian Abbas, et al.
Published: (2009-10-01)

Variation in blood microbial lipopolysaccharide (LPS) contributes to immune reconstitution in response to suppressive antiretroviral therapy in HIV
by: Zhenwu Luo, et al.
Published: (2022-06-01)

Comprehensive Analysis of Ferroptosis- and Immune-Related Signatures to Improve the Prognosis and Diagnosis of Kidney Renal Clear Cell Carcinoma
by: Xiao-Liang Xing, et al.
Published: (2022-05-01)

Ferroptosis and tumor immunotherapy: A promising combination therapy for tumors
by: Huazhong Cai, et al.
Published: (2023-02-01)

Thymic Function as a Predictor of Immune Recovery in Chronically HIV-Infected Patients Initiating Antiretroviral Therapy
by: Rita Rb-Silva, et al.
Published: (2019-02-01)

Ovarian stimulation in assisted reproductive technology cycles for varied patient profiles: An Indian perspective
by: Padma Rekha Jirge, et al.
Published: (2022-01-01)

Cryptococcal prostatic abscess in a HIV infected patient with immune reconstitutition inflammatory syndrome
by: Sunil Raviraj Kothakota, et al.
Published: (2020-01-01)