Distinctive HBV Replication Capacity and Susceptibility to Tenofovir Induced by a Polymerase Point Mutation in Hepatoma Cell Lines and Primary Human Hepatocytes

Distinctive HBV Replication Capacity and Susceptibility to Tenofovir Induced by a Polymerase Point Mutation in Hepatoma Cell Lines and Primary Human Hepatocytes

Tenofovir disoproxil fumarate (TDF) has been regarded as the most potent drug for treating patients with chronic hepatitis B (CHB). However recently, viral mutations associated with tenofovir have been reported. Here, we found a CHB patient with suboptimal response after more than 4 years of TDF tre...

Full description

Bibliographic Details
Main Authors: Ah Ram Lee, Ju-Yeon Cho, Jong Chul Kim, Mehrangiz Dezhbord, Soo Yeun Choo, Chang Hyun Ahn, Na Yeon Kim, Jae Jin Shin, Soree Park, Eun-Sook Park, Juhee Won, Dong-Sik Kim, Jeong-Hoon Lee, Kyun-Hwan Kim
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
hepatitis B virus
tenofovir disoproxil fumarate (TDF)
reverse transcription
nucleos(t)ide analog
drug resistance
Online Access:https://www.mdpi.com/1422-0067/22/4/1606

Internet

https://www.mdpi.com/1422-0067/22/4/1606

Similar Items