Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection.

Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection.

Cytotoxic CD8(+) T cells (CTLs) contain virus infections through the release of granules containing both perforin and granzymes. T cell 'exhaustion' is a hallmark of chronic persistent viral infections including HIV. The inhibitory regulatory molecule, T cell Immunoglobulin and Mucin domai...

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Bibliographic Details
Main Authors: Ali Sakhdari, Shariq Mujib, Bahareh Vali, Feng Yun Yue, Sonya MacParland, Kiera Clayton, Richard Bradley Jones, Jun Liu, Erika Yue Lee, Erika Benko, Colin Kovacs, Jennifer Gommerman, Rupert Kaul, Mario A Ostrowski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3390352?pdf=render

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http://europepmc.org/articles/PMC3390352?pdf=render

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