Multiparameter analysis of timelapse imaging reveals kinetics of megakaryocytic erythroid progenitor clonal expansion and differentiation

Multiparameter analysis of timelapse imaging reveals kinetics of megakaryocytic erythroid progenitor clonal expansion and differentiation

Abstract Single-cell assays have enriched our understanding of hematopoiesis and, more generally, stem and progenitor cell biology. However, these single-end-point approaches provide only a static snapshot of the state of a cell. To observe and measure dynamic changes that may instruct cell fate, we...

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Main Authors: Vanessa M. Scanlon, Evrett N. Thompson, Betty R. Lawton, Maria Kochugaeva, Kevinminh Ta, Madeline Y. Mayday, Juliana Xavier-Ferrucio, Elaine Kang, Nicole M. Eskow, Yi-Chien Lu, Nayoung Kwon, Anisha Laumas, Matthew Cenci, Kalyani Lawrence, Katie Barden, Shannon T. Larsuel, Fiona E. Reed, Gabriela Peña-Carmona, Ashley Ubbelohde, June P. Lee, Shakthi Boobalan, Yvette Oppong, Rachel Anderson, Colby Maynard, Kaylie Sahirul, Callista Lajeune, Varsha Ivathraya, Tiffany Addy, Patricia Sanchez, Colin Holbrook, Andrew Tri Van Ho, James S. Duncan, Helen M. Blau, Andre Levchenko, Diane S. Krause
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-19013-x

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https://doi.org/10.1038/s41598-022-19013-x

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