Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation.

Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation.

The rapid and robust synthesis of polymers of adenosine diphosphate (ADP)-ribose (PAR) chains, primarily catalyzed by poly(ADP-ribose) polymerase 1 (PARP1), is crucial for cellular responses to DNA damage. However, the precise mechanisms through which PARP1 is activated and PAR is robustly synthesiz...

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Bibliographic Details
Main Authors: Xin Sun, Kai Fu, Andrea Hodgson, Eric M Wier, Matthew G Wen, Olena Kamenyeva, Xue Xia, Lily Y Koo, Fengyi Wan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-09-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC5026359?pdf=render

Internet

http://europepmc.org/articles/PMC5026359?pdf=render

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