Therapeutic targeting of histone lysine demethylase KDM4B blocks the growth of castration-resistant prostate cancer

Therapeutic targeting of histone lysine demethylase KDM4B blocks the growth of castration-resistant prostate cancer

Epigenetics is an emerging mechanism for tumorigenesis. Treatment that targets epigenetic regulators is becoming an attractive strategy for cancer therapy. The role of epigenetic therapy in prostate cancer (PCa) remains elusive. Previously we demonstrated that upregulation of histone lysine demethyl...

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Bibliographic Details
Main Authors: Lingling Duan, Yu-An Chen, Yanping Liang, Zhenhua Chen, Jun Lu, Yong Fang, Jiazheng Cao, Jian Lu, Hongwei Zhao, Rey-Chen Pong, Elizabeth Hernandez, Payal Kapur, Tram Anh T. Tran, Tristan Smith, Elisabeth D. Martinez, Jung-Mo Ahn, Jer-Tsong Hsieh, Jun-hang Luo, Zhi-Ping Liu
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Histone lysine demethylase
KDM4B
KDM inhibitor
Castration-resistant prostate cancer
Prostate cancer therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222014664

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http://www.sciencedirect.com/science/article/pii/S0753332222014664

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