Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex

Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex

3’ polyadenylation is a key step in eukaryotic mRNA biogenesis. In mammalian cells, this process is dependent on the recognition of the hexanucleotide AAUAAA motif in the pre-mRNA polyadenylation signal by the cleavage and polyadenylation specificity factor (CPSF) complex. A core CPSF complex compri...

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Bibliographic Details
Main Authors: Marcello Clerici, Marco Faini, Ruedi Aebersold, Martin Jinek
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
mRNA
polyadenylation
X-ray crystallography
mass spectrometry
RNA processing
protein-RNA interactions
Online Access:https://elifesciences.org/articles/33111

Internet

https://elifesciences.org/articles/33111

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