Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex
3’ polyadenylation is a key step in eukaryotic mRNA biogenesis. In mammalian cells, this process is dependent on the recognition of the hexanucleotide AAUAAA motif in the pre-mRNA polyadenylation signal by the cleavage and polyadenylation specificity factor (CPSF) complex. A core CPSF complex compri...
Main Authors: | Marcello Clerici, Marco Faini, Ruedi Aebersold, Martin Jinek |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2017-12-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/33111 |
Similar Items
-
Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis
by: Lena Maria Muckenfuss, et al.
Published: (2022-09-01) -
Molecular details of the CPSF73-CPSF100 C-terminal heterodimer and interaction with Symplekin
by: Stéphane Thore, et al.
Published: (2023-11-01) -
Analysis of RNA Polyadenylation in Healthy and Osteoarthritic Human Articular Cartilage
by: Phaedra Winstanley-Zarach, et al.
Published: (2023-04-01) -
Molecular architecture of the human tRNA ligase complex
by: Alena Kroupova, et al.
Published: (2021-12-01) -
Structural insights into molecular mechanism for N6-adenosine methylation by MT-A70 family methyltransferase METTL4
by: Luo, Q, et al.
Published: (2022)