In Vivo Induction of Regulatory T Cells Via CTLA‐4 Signaling Peptide to Control Autoimmune Encephalomyelitis and Prevent Disease Relapse

In Vivo Induction of Regulatory T Cells Via CTLA‐4 Signaling Peptide to Control Autoimmune Encephalomyelitis and Prevent Disease Relapse

Abstract Regulatory T cells play a key role in immune tolerance to self‐antigens, thereby preventing autoimmune diseases. However, no drugs targeting Treg cells have been approved for clinical trials yet. Here, a chimeric peptide is generated by conjugation of the cytoplasmic domain of CTLA‐4 (ctCTL...

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Bibliographic Details
Main Authors: Gil‐Ran Kim, Won‐Ju Kim, Sangho Lim, Hong‐Gyun Lee, Ja‐Hyun Koo, Kyung‐Ho Nam, Sung‐Min Kim, Sung‐Dong Park, Je‐Min Choi
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Advanced Science
Subjects:
autoimmunity
CTLA‐4
EAE (experimental autoimmune encephalomyelitis)
multiple sclerosis
regulatory T cells
Online Access:https://doi.org/10.1002/advs.202004973

Internet

https://doi.org/10.1002/advs.202004973

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