Novel Molecular Determinants of Response or Resistance to Immune Checkpoint Inhibitor Therapies in Melanoma

Novel Molecular Determinants of Response or Resistance to Immune Checkpoint Inhibitor Therapies in Melanoma

BackgroundImmune checkpoint inhibitor (ICI) therapy dramatically prolongs melanoma survival. Currently, the identified ICI markers are sometimes ineffective. The objective of this study was to identify novel determinants of ICI efficacy.MethodsWe comprehensively curated pretreatment somatic mutation...

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Bibliographic Details
Main Authors: Wenjing Zhang, Yujia Kong, Yuting Li, Fuyan Shi, Juncheng Lyu, Chao Sheng, Suzhen Wang, Qinghua Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
melanoma
immunotherapy
SMGs
mutational signatures
molecular subtypes
predictive biomarkers
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.798474/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.798474/full

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