Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism
Nonsense-mediated mRNA decay (NMD) is both a mechanism for rapidly eliminating mRNAs carrying a premature termination codon and a pathway that regulates many genes. This implies that NMD must be subject to regulation in order to allow, under certain physiological conditions, the expression of genes...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/1/141 |
| _version_ | 1797495555095527424 |
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| author | Fabrice Lejeune |
| author_facet | Fabrice Lejeune |
| author_sort | Fabrice Lejeune |
| collection | DOAJ |
| description | Nonsense-mediated mRNA decay (NMD) is both a mechanism for rapidly eliminating mRNAs carrying a premature termination codon and a pathway that regulates many genes. This implies that NMD must be subject to regulation in order to allow, under certain physiological conditions, the expression of genes that are normally repressed by NMD. Therapeutically, it might be interesting to express certain NMD-repressed genes or to allow the synthesis of functional truncated proteins. Developing such approaches will require a good understanding of NMD regulation. This review describes the different levels of this regulation in human cells. |
| first_indexed | 2024-03-10T01:52:01Z |
| format | Article |
| id | doaj.art-76f6adab935e46c8ae8794a47b57ea85 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T01:52:01Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-76f6adab935e46c8ae8794a47b57ea852023-11-23T13:04:29ZengMDPI AGBiomedicines2227-90592022-01-0110114110.3390/biomedicines10010141Nonsense-Mediated mRNA Decay, a Finely Regulated MechanismFabrice Lejeune0Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277—CANTHER—Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, FranceNonsense-mediated mRNA decay (NMD) is both a mechanism for rapidly eliminating mRNAs carrying a premature termination codon and a pathway that regulates many genes. This implies that NMD must be subject to regulation in order to allow, under certain physiological conditions, the expression of genes that are normally repressed by NMD. Therapeutically, it might be interesting to express certain NMD-repressed genes or to allow the synthesis of functional truncated proteins. Developing such approaches will require a good understanding of NMD regulation. This review describes the different levels of this regulation in human cells.https://www.mdpi.com/2227-9059/10/1/141nonsense-mediated mRNA decayUPF proteinsregulationgene expressiontherapeutic perspectives |
| spellingShingle | Fabrice Lejeune Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism Biomedicines nonsense-mediated mRNA decay UPF proteins regulation gene expression therapeutic perspectives |
| title | Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism |
| title_full | Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism |
| title_fullStr | Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism |
| title_full_unstemmed | Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism |
| title_short | Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism |
| title_sort | nonsense mediated mrna decay a finely regulated mechanism |
| topic | nonsense-mediated mRNA decay UPF proteins regulation gene expression therapeutic perspectives |
| url | https://www.mdpi.com/2227-9059/10/1/141 |
| work_keys_str_mv | AT fabricelejeune nonsensemediatedmrnadecayafinelyregulatedmechanism |