The interdependent network of gene regulation and metabolism is robust where it needs to be
Although networks of interacting genes and metabolic reactions are interdependent, they have largely been treated as separate systems. Here the authors apply a statistical framework for interdependent networks to E. coli, and show that it is sensitive to gene and protein perturbations but robust aga...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00587-4 |
| _version_ | 1818427388210446336 |
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| author | David F. Klosik Anne Grimbs Stefan Bornholdt Marc-Thorsten Hütt |
| author_facet | David F. Klosik Anne Grimbs Stefan Bornholdt Marc-Thorsten Hütt |
| author_sort | David F. Klosik |
| collection | DOAJ |
| description | Although networks of interacting genes and metabolic reactions are interdependent, they have largely been treated as separate systems. Here the authors apply a statistical framework for interdependent networks to E. coli, and show that it is sensitive to gene and protein perturbations but robust against metabolic changes. |
| first_indexed | 2024-12-14T14:44:56Z |
| format | Article |
| id | doaj.art-76f71895ef464ff285dfb42fd0b7998e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T14:44:56Z |
| publishDate | 2017-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-76f71895ef464ff285dfb42fd0b7998e2022-12-21T22:57:18ZengNature PortfolioNature Communications2041-17232017-09-01811910.1038/s41467-017-00587-4The interdependent network of gene regulation and metabolism is robust where it needs to beDavid F. Klosik0Anne Grimbs1Stefan Bornholdt2Marc-Thorsten Hütt3Institute for Theoretical Physics, University of BremenDepartment of Life Sciences and Chemistry, Jacobs UniversityInstitute for Theoretical Physics, University of BremenDepartment of Life Sciences and Chemistry, Jacobs UniversityAlthough networks of interacting genes and metabolic reactions are interdependent, they have largely been treated as separate systems. Here the authors apply a statistical framework for interdependent networks to E. coli, and show that it is sensitive to gene and protein perturbations but robust against metabolic changes.https://doi.org/10.1038/s41467-017-00587-4 |
| spellingShingle | David F. Klosik Anne Grimbs Stefan Bornholdt Marc-Thorsten Hütt The interdependent network of gene regulation and metabolism is robust where it needs to be Nature Communications |
| title | The interdependent network of gene regulation and metabolism is robust where it needs to be |
| title_full | The interdependent network of gene regulation and metabolism is robust where it needs to be |
| title_fullStr | The interdependent network of gene regulation and metabolism is robust where it needs to be |
| title_full_unstemmed | The interdependent network of gene regulation and metabolism is robust where it needs to be |
| title_short | The interdependent network of gene regulation and metabolism is robust where it needs to be |
| title_sort | interdependent network of gene regulation and metabolism is robust where it needs to be |
| url | https://doi.org/10.1038/s41467-017-00587-4 |
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