Effects of aberrant Pax6 gene dosage on mouse corneal pathophysiology and corneal epithelial homeostasis.

Effects of aberrant Pax6 gene dosage on mouse corneal pathophysiology and corneal epithelial homeostasis.

Altered dosage of the transcription factor PAX6 causes multiple human eye pathophysiologies. PAX6⁺/⁻ heterozygotes suffer from aniridia and aniridia-related keratopathy (ARK), a corneal deterioration that probably involves a limbal epithelial stem cell (LESC) deficiency. Heterozygous Pax6(+/Sey-Neu)...

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Bibliographic Details
Main Authors: Richard L Mort, Adam J Bentley, Francis L Martin, J Martin Collinson, Panagiotis Douvaras, Robert E Hill, Steven D Morley, Nigel J Fullwood, John D West
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3248408?pdf=render

Internet

http://europepmc.org/articles/PMC3248408?pdf=render

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