Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations

Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations

A physiologically based pharmacokinetic (PBPK) model of selegiline (SEL), and its metabolites, was developed in silico to evaluate the disposition differences between healthy and special populations. SEL is metabolized to methamphetamine (MAP) and desmethyl selegiline (DMS) by several CYP enzymes. C...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Santosh Kumar Puttrevu, Sumit Arora, Sebastian Polak, Nikunj Kumar Patel
Format: Artykuł
Język:English
Wydane: MDPI AG 2020-09-01
Seria:Pharmaceutics
Hasła przedmiotowe:
selegiline
transdermal
multi-phase multi-layer mechanistic dermal absorption (mpml-mechderma) model
parent and metabolite PBPK model
special populations
Dostęp online:https://www.mdpi.com/1999-4923/12/10/942

Internet

https://www.mdpi.com/1999-4923/12/10/942

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