Antibody blockade of Jagged1 attenuates choroidal neovascularization

Antibody blockade of Jagged1 attenuates choroidal neovascularization

Abstract Antibody-based blocking of vascular endothelial growth factor (VEGF) reduces choroidal neovascularization (CNV) and retinal edema, rescuing vision in patients with neovascular age-related macular degeneration (nAMD). However, poor response and resistance to anti-VEGF treatment occurs. We re...

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Bibliographic Details
Main Authors: Torleif Tollefsrud Gjølberg, Jonas Aakre Wik, Hanna Johannessen, Stig Krüger, Nicola Bassi, Panagiotis F. Christopoulos, Malin Bern, Stian Foss, Goran Petrovski, Morten C. Moe, Guttorm Haraldsen, Johanna Hol Fosse, Bjørn Steen Skålhegg, Jan Terje Andersen, Eirik Sundlisæter
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38563-w

Internet

https://doi.org/10.1038/s41467-023-38563-w

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