Expression of Claudin-4 in Lung Ischemia-Reperfusion Injury in Experimental Lung Transplantation

Expression of Claudin-4 in Lung Ischemia-Reperfusion Injury in Experimental Lung Transplantation

During lung transplantation (LTx), the warm (WIT) and cold ischemia time (CIT) predispose to ischemia-reperfusion injury (LIRI) and the primary graft dysfunction (PGD). LIRI induces edema by changes in tight junctions (TJs) of pulmonary epithelial and endothelial cells. Claudin-4 (CLDN4) is a compon...

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Bibliographic Details
Main Authors: Antonia Luna-Flores, J. Raúl Olmos-Zuñiga, Rogelio Jasso-Victoria, Miguel Gaxiola-Gaxiola, Teresa Aguirre-Pérez, Victor Ruiz, Rogelio García-Torrentera, Mariana Silva-Martínez, Edgar Zenteno, Gabriel Gutierrez-Ospina, Patricio Santillan-Doherty
Format: Article
Language:English
Published: Taylor & Francis Group 2022-01-01
Series:Journal of Investigative Surgery
Subjects:
lung transplantation
lung ischemia-reperfusion injury
edema
claudin 4 expression
Online Access:http://dx.doi.org/10.1080/08941939.2020.1815253

Internet

http://dx.doi.org/10.1080/08941939.2020.1815253

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