Kaposi’s Sarcoma-Associated Herpesvirus ORF50 Protein Represses Cellular MDM2 Expression via Suppressing the Sp1- and p53-Mediated Transactivation

Kaposi’s Sarcoma-Associated Herpesvirus ORF50 Protein Represses Cellular MDM2 Expression via Suppressing the Sp1- and p53-Mediated Transactivation

The Kaposi’s sarcoma-associated herpesvirus (KSHV)-encoded ORF50 protein is a potent transcriptional activator essential for triggering KSHV lytic reactivation. Despite extensive studies, little is known about whether ORF50 possesses the ability to repress gene expression or has an antagonistic acti...

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Bibliographic Details
Main Authors: Chia-I Lin, Shie-Shan Wang, Chien-Hui Hung, Pey-Jium Chang, Lee-Wen Chen
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
KSHV
ORF50
MDM2
Sp1
p53
transcriptional repression
Online Access:https://www.mdpi.com/1422-0067/23/15/8673

Internet

https://www.mdpi.com/1422-0067/23/15/8673

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