Legumain Functions as a Transient TrkB Sheddase

Legumain Functions as a Transient TrkB Sheddase

While primarily found in endo-lysosomal compartments, the cysteine protease legumain can also translocate to the cell surface if stabilized by the interaction with the RGD-dependent integrin receptor αVβ3. Previously, it has been shown that legumain expression is inversely related to BDNF-TrkB activ...

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Bibliographic Details
Main Authors: Christoph Holzner, Katharina Böttinger, Constantin Blöchl, Christian G. Huber, Sven O. Dahms, Elfriede Dall, Hans Brandstetter
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
lysomale proteases
neurotrophins
tyrosine receptor kinase
functional processing
dimerization
Online Access:https://www.mdpi.com/1422-0067/24/6/5394

Internet

https://www.mdpi.com/1422-0067/24/6/5394

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