Innovative Bioprocess Strategies Combining Physiological Control and Strain Engineering of Pichia pastoris to Improve Recombinant Protein Production

The combination of strain and bioprocess engineering strategies should be considered to obtain the highest levels of recombinant protein production (RPP) while assuring product quality and process reproducibility of heterologous products. In this work, two complementary approaches were investigated...

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Bibliographic Details
Main Authors: Arnau Gasset, Xavier Garcia-Ortega, Javier Garrigós-Martínez, Francisco Valero, José Luis Montesinos-Seguí
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.818434/full